Biological properties of new acyl derivatives of tylosin.

Physico-chemical properties of new acyl derivatives of tylosin produced by microbial transformation.

By microbial transformation of tylosin (I), the following eight new acyl derivatives were obtained: 3-acetyltylosin (II), 3-propionyltylosin (III), 4"-butyryltylosin (IV), 4"-isovaleryltylosin (V), 3-acetyl-4"-butyryltylosin (VI), 3-acetyl-4"-isovaleryltylosin (VII), 3-propionyl-4"-butyryltylosin (VIII) and 3-propionyl-4"-isovaleryltylosin (IX).

Structure-activity relationship studies on 4''-O-acyltylosin derivatives: significance of their 23-O-mycinosyl and 4''-O-acyl moieties in antimicrobial activity against macrolide-resistant microbes.

Essential roles for both the 23-O-mycinosyl and 4''-O-acyl moieties of 4''-O-acyltylosin derivatives in the expression of antimicrobial activity against multiple macrolide-resistant strains of Staphylococci and mycoplasmas were demonstrated by in vitro comparison of the MICs of erythromycin, josamycin, tylosin and its 3- and 4''-O-acyl derivatives, demycinosyltylosin (DMT) and its 3- and 4''-O-...

Syntheses and antimicrobial activities of 9-O-acyl derivatives of tylosin and demycarosyltylosin.

A New Method for the Synthesis of New Derivatives of “1,3- diaryl-2-n-azaphenalene and n-acyl-1,3-diaryl-2-N-azephenylene” by Using Nano catalyst and Analyzing Antibacterial Activity of Structures

In this research, synthesized well derivatives of 1,3-diaryl-2-N-azaphenalene and N-acyl-1.3-diaryl-2-N- azaphenalene as a macromolecule in the presence of nanoparticles (Fe3O4 coated with L-Arginine)as a magnetic Nano catalyst in a one-pot reaction of compounds 7.2-Naphthalene diol, aldehydes,ammonium derivatives (ammonium acetate or ammonium hydro phosphates) and solvent (wa...

Synthesis, Characterization and Antibacterial Activity Studies of Some N-Acyl-N'-aryl Thiourea Derivatives

Some N¬-acyl-N'-aryl thiourea derivatives 4(a-f) have been prepared by the reaction of acyl halides ammonium thiocyanate and aryl amines. The structures of synthesized compounds have been characterized by IR, 1HNMR spectral studies. The synthesized compounds 5(a-f) have been screened for antibacterial activity. The effect of the structure of the investigated compounds on the antibacterial activ...